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amgen science research bone bone health bone biology bone science bone disease biotechnology biotech fracture bone cancer cancer osteoblasts osteoclasts rankl bone decay metastatic bone cancer bone marrow bone tissue remodeling bone loss bone formation prostate lung breast malignancies tumors metastasize growth factors resorption bone metastases metastases osteolytic osteoblastic bone destruction tumor cells cytokines skeletal-related events SRE